TWiST 500 interviews with Cortical Labs, Turing, AND Mercor | E2159

Today’s show:

Alex is back with three more awesome interviews with founders on the bleeding edge of innovative tech.

- Dr. Hon Weng Chong walks us through the basics of biological computing and Cortical Labs’ first-ever commercial computer running on living human cells.
- Turing founder Jonathan Siddarth unpacks the secrets of LLM benchmarking, and explains why even our most advanced tests need to get much much harder right away.
- Finally, Mercor founder Brendan Foody on how AI is about to reinvent the hiring process, and marrying the effectiveness of recruiters with the ease of online job boards.

It’s three — count ’em, three — can’t miss TWiST interviews guaranteed to make you smarter

Timestamps:

(0:00) OpenAI’s GPT-5: When is it coming out? Is it going to be TOO smart?
(08:06) Cortical Labs’ Hon Weng Chong on the electric connection between neuroscience and machine learning
(10:20) Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist today!
(11:27) Show Continues…
(15:17) The extreme difficulty of going from the lab to a shippable product
(20:00) .TECH: Say it without saying it. Head to http://www.get.tech/twist or your favorite registrar to get a clean, sharp .tech domain today.
(21:05) Show Continues…
(28:15) Why data is a factor of time
(29:52) AWS Activate - AWS Activate helps startups bring their ideas to life. Apply to AWS Activate today to learn more. Visit aws.amazon.com/startups/credits
(31:16) Show Continues…
(42:44) Turing CEO Jonathan Siddarth explains why it’s so important to keep benchmarking our LLMs
(47:24) What it means when a model “saturates” a test, and why benchmarks need to get HARDER
(50:22) What happens with the LLMs can answer all of our smartest questions?
(53:44) AI Agents train in gyms? Wait, really?
(01:01:33) Coding teaches models how to think, and more training mysteries don’t understand
(01:03:11) Brendan Foody from Mercor explains the “matching problem” that makes hiring such a pain
(01:07:02) How Mercor combines a job board’s distribution with the value of a recruitment agency
(01:10:49) Brendan recalls building his first AI interviewer in his college dorm
(01:20:16) Mercor has the opposite of a retention problem and crazy growth

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