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In this episode of AI Basics, Jason sits down with CapitalG partner Jill Chase to break down how AI is reshaping the startup ecosystem — from founders to investors to incumbents. They cover how CapitalG (Alphabet’s independent growth fund) thinks about the AI stack, why speed alone isn’t enough for startups today, and how to build durable advantages in a world where anyone can copy your product. Jill shares insights from portfolio companies like Motif (next-gen CAD for architecture) and Abridge (AI-powered doctor’s scribe), plus how startups can use AI “in the business” (product) and “on the business” (ops, GTM, etc). They also explore the transition from copilots to agents — and what that means for the next wave of software. If you’re building or investing in AI, this is a must-watch.

Timestamps:
(0:00) Jason kicks off the show
(1:10) CapitalG's investment strategy in AI
(3:04) Understanding value in AI investments
(5:16) Durability in AI startups and market challenges
(10:18) Practical applications of AI in business
(17:52) Case studies of successful AI startups
(21:35) Building massive businesses with small teams
(23:55) Evolution from AI copilots to autonomous agents

Uncover more valuable insights from AI leaders in Google Cloud's 'Future of AI: Perspectives for Startups' report. Discover what 23 AI industry leaders think about the future of AI—and how it impacts your business. Read their perspectives here: https://goo.gle/futureofai

Check out all of the Startup Basics episodes here: https://thisweekinstartups.com/basics
Check out Google Cloud: https://cloud.google.com/
Check out CapitalG: https://www.capitalg.com/

Follow Jill:
LinkedIn: https://www.linkedin.com/in/jill-greenberg-chase-53747538/
X: https://x.com/jillchase124

Follow Jason:
X: https://twitter.com/Jason
LinkedIn: https://www.linkedin.com/in/jasoncalacanis

Follow TWiST:
Twitter: https://twitter.com/TWiStartups
YouTube: https://www.youtube.com/thisweekin
Instagram: https://www.instagram.com/thisweekinstartups
TikTok: https://www.tiktok.com/@thisweekinstartups
Substack: https://twistartups.substack.com

Today’s show: Jason, Alex, and Lon discuss the rise of LMArena as it spins out into a full-fledged startup, what that means for AI benchmarking, and how it could monetize its growing community. They also dive into the emerging value of application-layer AI startups and why OpenAI’s acquisition spree is just beginning. Plus, branding expert Scott Bair drops tactical design tips for founders—from logos to product UX—that can give your startup the edge.

(0:00) AI companies and value accrual in the AI rush
(1:29) Productivity in remote work
(5:12) Overview of LM Arena as a startup
(7:22) Business models for AI and benchmarking
(10:05) Fidelity Private Shares℠ - Visit ⁠https://fidelityprivateshares.com⁠! Mention our podcast and receive 20% off your first-year paid subscription.
(14:16) Milestone-based investing and early-stage funding
(16:34) OpenAI's acquisition moves and AI market dynamics
(20:12) OpenPhone - Streamline and scale your customer communications with OpenPhone. Get 20% off your first 6 months at https://www.openphone.com/⁠twist
(21:15) Intangible value and strategic acquisitions in AI
(24:30) High valuations and consumer AI pricing models
(26:00) The rise of drone startups and autonomous weapon systems
(29:46) Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit http://northwestregisteredagent.com/twist today!
(32:00) Venture interest in drones and geopolitical considerations
(32:30) Branding, design, and founder questions
(43:51) Brand mission and work environment culture
(47:10) Savage my startup and live clinic
(49:30) Logo design and color theory
(56:29) Designing great websites and apps
(59:29) Founder University website review
(1:00:49) Closing remarks and social media plugs

Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com

Check out the TWIST500: https://www.twist500.com

Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp


Check out:
Lunour: https://www.lunour.com/
Founder Fridays: https://www.founderfridays.tech/
Founder University: https://www.founder.university/


Follow Lon:
X: https://x.com/lons

Follow Alex:
X: https://x.com/alex
LinkedIn: https://www.linkedin.com/in/alexwilhelm

Follow Jason:
X: https://twitter.com/Jason
LinkedIn: https://www.linkedin.com/in/jasoncalacanis


Thank you to our partners:

(10:05) Fidelity Private Shares℠ - Visit ⁠https://fidelityprivateshares.com⁠! Mention our podcast and receive 20% off your first-year paid subscription.

(20:12) OpenPhone - Streamline and scale your customer communications with OpenPhone. Get 20% off your first 6 months at www.openphone.com/⁠twist

(29:46) Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit http://northwestregisteredagent.com/twist today!

Today’s show: Jason and Lon break down the biggest stories in tech and startups this week: OpenAI’s new models are powerful but glitchy, Meta’s internal docs hint that Zuck knows the Facebook friends graph is toast, and fintech startup TapCheck might actually be doing some good. Plus, robot lifeguards and humanoid races — the wildest videos of the week and what they mean. Then, Alex sits down with Jason Reminick, founder of Thalamus, the platform that helps match medical residents to hospitals (with 85% market share!). They talk about becoming a Public Benefit Corp and how Thalamus is tackling the doctor shortage in the U.S.

Timestamps:
(0:00) Jason kicks off the show
(1:43) OpenAI's new models and issues with Wikipedia as AI knowledge bases
(8:27) FTC antitrust case around Meta; breaking up big tech
(11:13) Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.squarespace.com/TWIST
(13:04) Tapcheck's impact on employee retention and minimum wage variations
(19:56) Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit http://northwestregisteredagent.com/twist today!
(24:31) New company Revel's safety software
(27:14) Humanoid robot marathon in Beijing
(30:15) Brex. Get the business account trusted by 1 in 3 US startups at ⁠https://brex.com/banking-solutions
(35:46) New color discovery “Olo”
(40:30) Blue Sky is Falling: Robots, delivery, surveillance, and privacy concerns
(55:20) Alex sits down with Jason Reminick of Thalamus
(56:01) Thalamus and the medical residency application process
(59:42) AI in residency applications and standardizing medical school grades
(1:03:30) Thalamus' market share and collaboration with medical associations
(1:10:08) Impact of budget cuts on rural hospitals and business model expansion

Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com
Check out the TWIST500: https://www.twist500.com
Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp

Links from episode:
Check out Thalamus: https://www.thalamusgme.com/
Check out the Robot Lifeguard: https://oceanalpha.com/product-item/dolphin1/
Check out TapCheck: https://www.tapcheck.com/

Follow: Jason Reminick
LinkedIn: https://www.linkedin.com/in/jason-reminick-md-mba-ms-bb251645/
Thalamus on X: https://x.com/ThalamusGME/status/1757812695787581485

Follow Lon:
X: https://x.com/lons

Follow Alex:
X: https://x.com/alex
LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm

Follow Jason:
X: https://twitter.com/Jason
LinkedIn: https://www.linkedin.com/in/jasoncalacanis

Thank you to our partners:
(11:13) Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST
(19:56) Northwest Registered Agent. Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit http://northwestregisteredagent.com/twist today!
(30:15) Brex. Get the business account trusted by 1 in 3 US startups at ⁠https://brex.com/banking-solutions

All rights for the video shared and linked below belong to the original copyright holder, and we are using the footage under the principle of fair use.

Listen here:
Apple: https://podcasts.apple.com/us/podcast/this-week-in-startups-audio/id315114957
Spotify: https://open.spotify.com/show/6ULQ0ewYf5zmsDgBchlkr9
Overcast: https://overcast.fm/itunes315114957/this-week-in-startups-audio

More from us:
Twitter: https://twitter.com/twistartups
Instagram: https://www.instagram.com/thisweekinstartups
Official site: https://thisweekinstartups.com

Subscribe to our YouTube to watch all full episodes:
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#startups #entrepreneurship #investing #angelinvesting #tech #news #business

Today’s show: Jason, Alex and Lon unpack the FTC’s lawsuit against Uber and what it could mean for subscription UX, break down how AI startup Cursor is growing faster than almost any SaaS company in history, and discuss how dark patterns, consumer trust, and regulatory scrutiny are reshaping product design. They also touch on the future of big tech breakups, share insights from founder Office Hours with GoShare CEO Shaun Savage, highlighting the power of focus, capital, and customer obsession for startups navigating turbulent markets.

(0:00) Episode Tease
(1:21) Jason talks about personal interests, frugality, and TWIST live tour
(7:29) Nick Huber's tweet on tariffs and business impact
(9:58) NetSuite - Download the CFO's Guide to AI and Machine Learning for free at https://www.netsuite.com/twist
(11:22) Market uncertainty and paused deals
(13:57) Trump's market feedback and tariffs
(16:29) Cursor's rapid revenue growth
(19:44) Gusto - Get three months free when you run your first payroll at http://gusto.com/twist
(21:16) Valuation discussion continuation and FTC sues Uber
(29:58) Vanta - Get $1000 off your SOC 2 at https://www.vanta.com/twist
(31:26) FTC dark patterns and consumer protection
(33:23) Founder Friday bracket competition: LifeStack vs MedSimple
(43:50) Introduction to GoShare and founder Shaun Savage
(45:57) Regulatory challenges in the gig economy and supply chain resilience
(57:37) Diversification strategies for GoShare's delivery professionals
(1:00:23) Benefits of office hours and brainstorming with portfolio companies
(1:01:26) Founder University and Launch Accelerator updates

Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com

Check out the TWIST500: https://www.twist500.com

Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp


Links from episode:
GoShare: https://goshare.co/
Founder University: https://www.founder.university/


Follow Shaun:
X: https://x.com/ShaunSavage19
LinkedIn: https://www.linkedin.com/in/shaunsavage/

Follow Lon:
X: https://x.com/lons

Follow Alex:
X: https://x.com/alex
LinkedIn: https://www.linkedin.com/in/alexwilhelm

Follow Jason:
X: https://twitter.com/Jason
LinkedIn: https://www.linkedin.com/in/jasoncalacanis

Thank you to our partners:

(9:58) NetSuite - Download the CFO's Guide to AI and Machine Learning for free at https://www.netsuite.com/twist

(19:44) Gusto - Get three months free when you run your first payroll at http://gusto.com/twist

(29:58) Vanta - Get $1000 off your SOC 2 at https://www.vanta.com/twist


All rights for the video shared and linked below belong to the original copyright holder, and we are using the footage under the principle of fair use.


Listen here:
Apple: https://podcasts.apple.com/us/podcast/this-week-in-startups-audio/id315114957
Spotify: https://open.spotify.com/show/6ULQ0ewYf5zmsDgBchlkr9
Overcast: https://overcast.fm/itunes315114957/this-week-in-startups-audio

More from us:
Twitter: https://twitter.com/twistartups
Instagram: https://www.instagram.com/thisweekinstartups
Official site: https://thisweekinstartups.com

Subscribe to our YouTube to watch all full episodes:
https://www.youtube.com/channel/UCkkhmBWfS7pILYIk0izkc3A?sub_confirmation=1

Subscribe to TWiST Clips for all the best moments:
https://www.youtube.com/channel/UCS7tJlcUA6PzVHEMo-X7ddg?sub_confirmation=1

#startups #entrepreneurship #investing #angelinvesting #tech #news #business

Is geoengineering a dangerous notion whose time has come? Scientists and entrepreneurs are testing radical ideas like solar radiation management and ocean fertilization - and finding funding for it.

0:00 - 2:20 A Terrible Idea
2:20 - 5:43 The Case for Solar Geoengineering
5:43 - 7:17 The Unknowns
7:17 - 8:21 Make Sunsets
8:21 - 11:06 The Market for SRM
11:06 - 13:31 Termination Shock
13:31 - 14:53 Ocean Fertilization Basics
14:53 - 18:53 Artificial Whale Poo
18:53 - 22:07 Science vs Business
22:07 - 23:34 Conclusion
23:34 - 24:00 Credits

Bloomberg Primer cuts through the complex jargon to reveal the business behind technologies poised to transform global markets. This six-part, planet-spanning series offers a comprehensive look at the "impossible" industries vying to shape our future. Watch the series: https://www.youtube.com/playlist?list=PLqq4LnWs3olWuFFpsiq0cFkGs7WMb6MtA

#Geoengineering #Science #Technology

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