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..the end..

Today’s show:

On a brand-new TWiST, Jason and Alex are asking why there are SO MANY note-taking AI apps?

Plus another death has been linked to ChatGPT… is it too easy to get past chatbot guardrails? How the US Navy could catch up with its international rivals… AND should Apple just buy a big AI company to help them catch up?

All that PLUS a visit from Colin Russ, Check out the full episode!

Timestamps:

(0:00) Intro, Jason’s checking out Notion’s new AI note taking app… is it time to cancel Granola?
(06:57) How Google Gemini’s new 2.5 Flash Image tool (formerly known as “nano-banana”) could change advertising
(10:28) Lemon.io - Get 15% off your first 4 weeks of developer time at https://lemon.io/twist
(11:40) Show Continues…
(17:50) Another death linked to ChatGPT… is it too easy to get around AI chatbot guardrails?
(19:26) Vouched - Trust for agents that’s built for builders like you. Check it out at http://vouched.id/twist
(20:34) Show Continues…
(28:10) Polymarket
(29:45) Northwest Registered Agent - Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist today!
(30:49) Show Continues…
(33:30) How Jason thinks the US Navy could catch up with China and other rivals, with help from startups
(40:01) Do Jason and Alex think Apple might REALLY buy a big, expensive AI company? Would that be admitting defeat?
(45:57) Colin Russ (@ThaaatColin) tells us about his viral X thread and why he’s worried about H1B visa fraud
(55:32) Jason’s solution for the H1B system
(01:08:25) Jason responds to Kara Swisher, who accused him sucking up to power
(01:19:07) Jason responds to his old pal Sam Harris, who thinks he’s loyal to the wrong people

*

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All rights for the video shared and linked below belong to the original copyright holder, and we are using the footage under the principle of fair use.


Listen here:
Apple: https://podcasts.apple.com/us/podcast/this-week-in-startups-audio/id315114957
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Overcast: https://overcast.fm/itunes315114957/this-week-in-startups-audio

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#startups #entrepreneurship #investing #angelinvesting #tech #news #business

Today’s show:

“KPop Demon Hunters” is one of the year’s biggest smashes… AFTER Sony sold it off to Netflix for cheap! Hear about what went wrong with one of the year’s worst deals…

PLUS Grok is counting on SPEED to help it outpace rivals… Nvidia’s big earnings report, and why everyone is watching that company in particular SO closely… PLUS a new Polymarket predicting the future of OpenAI!

Timestamps:

(0:00) How Sony missed out on “Kpop Demon Hunters”
(10:15) .TECH: Say it without saying it. Head to http://www.get.tech/twist or your favorite registrar to get a clean, sharp .tech domain today.
(11:20) Show continues…
(13:59) Why some politicians struggle so much on podcasts
(19:30) AWS Activate - AWS Activate helps startups bring their ideas to life. Apply to AWS Activate today to learn more. Visit https://www.aws.amazon.com/startups/credits
(20:53) Show continues…
(30:24) Alphasense - Get deeper insights into your business with the power of AI search and market intelligence. Start with a free trial at https://www.alpha-sense.com/twist
(31:37) Grok is relying on SPEED to outpace rivals… and it’s working
(41:23) Are AI companies playing a mega-budget game of chicken?
(42:31) Why everyone’s watching Nvidia’s earnings so closely
(47:50) Jason says he’ll NEVER go back to a non-AI browser
(53:32) Polymarket: Is OpenAI going to release their own browser?

*

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Thank you to our partners:

(10:15) .TECH: Say it without saying it. Head to http://www.get.tech/twist or your favorite registrar to get a clean, sharp .tech domain today.

(19:30) AWS Activate - AWS Activate helps startups bring their ideas to life. Apply to AWS Activate today to learn more. Visit https://www.aws.amazon.com/startups/credits

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All rights for the video shared and linked below belong to the original copyright holder, and we are using the footage under the principle of fair use.


Listen here:
Apple: https://podcasts.apple.com/us/podcast/this-week-in-startups-audio/id315114957
Spotify: https://open.spotify.com/show/6ULQ0ewYf5zmsDgBchlkr9
Overcast: https://overcast.fm/itunes315114957/this-week-in-startups-audio

More from us:
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Official site: https://thisweekinstartups.com

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#startups #entrepreneurship #investing #angelinvesting #tech #news #business

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#tech #news #tesla #elonmusk #elon

Today’s show:

Find out why it’s important to “get curious,” and more deep founder insights on a new TWiST.

Jason and Alex are back with a look at Robot vs. Human violence spilling out into the streets, Elon Musk’s vision for humanoid robots, and a reconsideration of Apple’s open-source AI models. Is the hardware giant not getting enough credit for its smaller-scale innovations?

Plus Grok has another hit model, AND a chat with Scale Social founder Runbin Dong about the importance of knowing your worth.

Timestamps:

(0:00) Robot vs. Human violence in the streets! Is anti-clanker behavior inevitable?
(05:13) Producer Claude’s company Anthropic is growing FAST, raising BIG money
(09:21) More on why Jason is convinced Tesla’s Optimus robots are the future
(10:35) Monarch Money - Get 50% Off Monarch Money, the all-in-one financial tool at http://www.monarchmoney.com/TWIST
(11:50) Show Continues…
(20:00) Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST
(21:19) Show Continues…
(23:31) Ask Jason: Should you get a ticket for messing with an autonomous vehicle?
(27:04) Is Apple not getting enough credit for its open-source AI models?
(30:30) AWS Activate - AWS Activate helps startups bring their ideas to life. Apply to AWS Activate today to learn more. Visit https://www.aws.amazon.com/startups/credits
(31:55) Show Continues…
(38:08) Grok has another hit AI model… how can anyone even keep track of this?!
(40:27) Runbin Dong of Scale Social stops by from ICELAND
(42:54) How Runbin’s job delivering homemade dumplings inspired his startup
(47:05) Why founders need to know their WORTH when pricing their products
(59:21) Jason’s advice for companies that are creating their own category

*

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Thank you to our partners:

(10:35) Monarch Money - Get 50% Off Monarch Money, the all-in-one financial tool at http://www.monarchmoney.com/TWIST

(20:00) Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST
(30:30) AWS Activate - AWS Activate helps startups bring their ideas to life. Apply to AWS Activate today to learn more. Visit https://www.aws.amazon.com/startups/credits

All rights for the video shared and linked below belong to the original copyright holder, and we are using the footage under the principle of fair use.

Listen here:
Apple: https://podcasts.apple.com/us/podcast/this-week-in-startups-audio/id315114957
Spotify: https://open.spotify.com/show/6ULQ0ewYf5zmsDgBchlkr9
Overcast: https://overcast.fm/itunes315114957/this-week-in-startups-audio

More from us:
Twitter: https://twitter.com/twistartups
Instagram: https://www.instagram.com/thisweekinstartups
Official site: https://thisweekinstartups.com

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#startups #entrepreneurship #investing #angelinvesting #tech #news #business

Kevin J. Tracey, MD is president and CEO of the Feinstein Institutes for Medical Research at Northwell Health, a pioneer of vagus nerve research and author of the recent book, The Great Nerve: The New Science of the Vagus Nerve and How to Harness Its Healing Reflexes.

This episode is brought to you by:

Eight Sleep Pod Cover 5 sleeping solution for dynamic cooling and heating: EightSleep.com/Tim (use code TIM to get $350 off your very own Pod 5 Ultra.)

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Tim Ferriss is one of Fast Company’s “Most Innovative Business People” and an early-stage tech investor/advisor in Uber, Facebook, Twitter, Shopify, Duolingo, Alibaba, and 50+ other companies. He is also the author of five #1 New York Times and Wall Street Journal bestsellers: The 4-Hour Workweek, The 4-Hour Body, The 4-Hour Chef, Tools of Titans and Tribe of Mentors. The Observer and other media have named him “the Oprah of audio” due to the influence of his podcast, The Tim Ferriss Show, which has exceeded 900 million downloads and been selected for “Best of Apple Podcasts” three years running.

Sign up for "5-Bullet Friday" (Tim's free weekly email newsletter): https://go.tim.blog/5-bullet-friday-yt/
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Follow Tim Ferriss on Instagram: https://www.instagram.com/timferriss/

[00:00] Start.
[00:38] Alleviating my skepticism about vagus nerve stimulation.
[05:21] SetPoint Medical receives FDA approval for vagus nerve stimulation device to treat rheumatoid arthritis.
[7:21] How Crohn's disease sufferer Kelly Owens went from a wheelchair to running up stairs in Amsterdam.
[14:47] Placebo effect concerns and what drove my interest in bioelectric medicine.
[19:52] Vagus nerve anatomy 101.
[25:57] What happens when the vagus nerve is stimulated.
[26:49] Accidental finding of brain-body inflammation connection.
[28:46] Bioelectronic medicine approach vs. pharmaceutical approach.
[31:25] Mice don't wheeze.
[33:22] Depression and inflammation connection: SSRIs may work through anti-inflammatory effects.
[36:00] My personal experience with vagus nerve stimulation and mood stability.
[37:40] The pros and cons of inflammation, and how controlling it may lead to even longer lifespans.
[44:09] Weighing the safety of VNS vs. biologics in cytokine suppression.
[49:55] Cold exposure, meditation, and breathing practices affecting the vagus nerve.
[52:32] A population-level increase in chronic inflammatory diseases.
[54:19] H. pylori: For when you can't blame stress, God, or the patient for that nagging ulcer.
[56:44] Stress, cortisol, and inflammation connections.
[59:13] SetPoint device vs. non-invasive alternatives for different patient populations.
[01:04:50] Auricular therapy's curious French origins.
[01:07:16] There's something fishy about this vestigial vagus nerve pathway.
[01:09:52] Brain imaging studies of ear stimulation.
[01:12:47] DARPA support and Geoff Ling's "What if it's yes?" attitude.
[01:15:47] Neurocognition and vagus nerve inputs.
[01:21:12] How Ulf Andersson turned his depression around with a TENS unit.
[01:25:55] Heart rate variability complexity and measurement challenges.
[01:27:09] A breathing exercise for directly controlling heart rate.
[01:29:27] Using a common antacid as a pharmacological vagus nerve stimulator during COVID.
[01:30:31] A call for more inflammation-based depression research.
[01:33:59] SSRIs and anti-inflammatory mechanisms in depression treatment.
[01:36:29] Interoception: The body's inflammatory signals reaching the brain via vagus nerve.
[01:37:32] Ulf's published protocol for TENS unit ear stimulation.
[01:38:46] VNS, acupuncture, fertility, and Martine Rothblatt.
[01:41:27] Chronic low back pain and an inflammatory overreaction analogy.
[01:42:50] Implications of Asya Rolls' engram research and inflammation memories in the brain.
[01:57:10] Cervical TENS vs. true VNS.
[02:01:51] Charles Sherrington's reflex theory and nervous system integration.
[02:06:55] Blue energy meditation and vagus nerve pathways with the Dalai Lama.
[02:11:21] Serious medical conditions vs. self-help approaches.

Corrections:
02:09:25 Dr. Tracey meant "Liz Blackburn."

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#sponsored Be kind to yourself this year! Using Zocdoc is FREE - visit https://www.Zocdoc.com/udy to find and instantly book an appointment with a top-rated, in-network doctor today.

Will Ray's girlfriend pass or fail this UDY loyalty test?! The results were SHOCKING!! Will this couple's relationship survive this loyalty test?! Watch till the end to see if she gets caught cheating on camera or passes the loyalty test!!!

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==== CHECK OUT OUR PREVIOUS TOP 10 GOLD DIGGERS / CHEATERS VIDEOS ====

DELON & SIERRA
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DEREK & AALIYAH
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====MEMO====
New 2025 reality tv episodes will drop soon! We will bring you the most intense cheating stories. Subscribe to see funny , epic, intense cheaters / gold diggers videos on YouTube and tiktok full of mystery and suspense! We will continue to test the loyalty of a person with material wealth in public (cheaters) as well as do other stuff!!! We will bring you the best, epic, and intense episodes and elaborate test!

Dr. Dominic D’Agostino is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition.

This episode is brought to you by:

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Tim Ferriss is one of Fast Company’s “Most Innovative Business People” and an early-stage tech investor/advisor in Uber, Facebook, Twitter, Shopify, Duolingo, Alibaba, and 50+ other companies. He is also the author of five #1 New York Times and Wall Street Journal bestsellers: The 4-Hour Workweek, The 4-Hour Body, The 4-Hour Chef, Tools of Titans and Tribe of Mentors. The Observer and other media have named him “the Oprah of audio” due to the influence of his podcast, The Tim Ferriss Show, which has exceeded 900 million downloads and been selected for “Best of Apple Podcasts” three years running.

Sign up for "5-Bullet Friday" (Tim's free weekly email newsletter): https://go.tim.blog/5-bullet-friday-yt/
Follow the Tim Ferriss Podcast: https://tim.blog/podcast/
Visit the Tim Ferriss Blog: https://tim.blog/
Follow Tim Ferriss on Twitter: https://twitter.com/tferriss/
Follow Tim Ferriss on Instagram: https://www.instagram.com/timferriss/
Like Tim Ferriss on Facebook: https://www.facebook.com/TimFerriss/

[00:00] Start
[00:42] Why I'm interested in ketogenic strategies for neurodegenerative prevention.
[02:17] Mary and Steve Newport's ketone-linked temporary cognitive improvements.
[04:31] A mechanisms overview for Alzheimer's/dementia.
[07:45] The immune system as longevity's "fifth horseman" — and why metabolic control is key.
[08:26] How to measure ketones and GKI.
[09:26] Fasting vs. ketogenic diet.
[10:48] There's nothing fishy about sardine fasting.
[15:05] My hiatal hernia discovery and increased cancer risk concerns.
[16:46] HSCRP as a superior biomarker to LDL for cardiovascular risk.
[18:39] Glucose tolerance testing revelations and CGM importance.
[24:12] Upgrading the metabolic machinery through keto without getting bored.
[27:43] What do do if you, like Dom and me, are among the 30% who suffer from cholesterol hyperabsorption.
[31:43] Dom's day-to-day diet regimen.
[37:29] How Dom optimizes his aging dogs with ketones, SARMs, and supplements.
[41:50] Supplementing for sleep disruption while fasting.
[45:20] Why Dom doesn't have misgivings about melatonin.
[46:09] Shingles prevention through fasting protocols.
[46:32] Immune system modulation: Innate vs. adaptive, vegan vs. ketogenic.
[50:15] Dom at 50-something: Current meal timing and composition.
[53:35] Blue zone observations: Greek and Sardinian longevity habits.
[54:39] Ketogenic diet initiation tips: MCT, electrolytes, and fasted cardio.
[01:01:49] Ketone metabolic therapy for cancer.
[01:04:54] The metabolic psychiatry revolution.
[01:08:49] The soothing effects of hyperbaric oxygen and ketosis on seizure sufferers.
[01:15:10] Metformin vs. berberine.
[01:18:29] The low-dose neuroprotective potential of GLP-1 drugs.
[01:21:44] NAD research: MIB-626 and stabilized forms for mitochondrial health.
[01:26:38] Idebenone, CoQ10, and the Deanna protocol for ALS.
[01:28:55] Dom's supplement short list: CoQ10, creatine, ketones, vitamin D, melatonin.
[01:31:36] KetoNutrition.org, Metabolic Health Summit, Audacious Nutrition, veteran-focused research protocols, and other parting thoughts.

Today’s show:

Jason and Alex are joined by Nuro’s Dave Ferguson to unpack the Lucid–Uber–Nuro deal aiming to launch fully driverless Gravity SUVs on Uber by 2026. They dig into why off-the-shelf sensors and Nvidia’s Thor chip drive costs down, how mapping 150 cities improves safety, and why lidar still matters for night and edge cases. Plus: lessons from Cruise’s collapse, how regulators think about safety multiples, and why autonomy could finally make rides cheaper than owning a car.

Timestamps:

(00:00) Show intro…

(06:23) Uber x Lucid x Nuro: why this 2026 robotaxi deal matters

(09:57) Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist

(11:13) What the self-driving “cost stack” really looks like in 2025

(14:08) Road-mapping at scale: Nuro’s 150-city data collection push

(15:38) Can AVs handle snow & rain? Weather rollout and Uber Black positioning

(20:05) Northwest Registered Agent - Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist today!

(21:07) Show Continues…

(24:24) Probabilistic vs. deterministic driving models — and the DARPA roots

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(31:08) Show Continues…

(35:38) Post-Cruise reality check: transparency, regulators & trust

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